The AngioJet rheolytic thrombectomy system is designed to remove thrombus with the Venturi-Bernoulli effect, with multiple high-velocity, high-pressure saline jets which are introduced through orifices in the distal tip of the catheter to create a localized low-pressure zone, resulting in a vacuum effect with the entrainment and dissociation of bulky thrombus. Rheolytic thrombectomy with the AngioJet catheter can reduce the thrombus burden in the setting of AMI and degenerated SVGs. The long-term follow-up appears to be favorable in patients treated with rheolytic thrombectomy in the setting of acute myocardial infarction over conventional primary angioplasty.