[Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids].
Copyright policy )[Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids].
To investigate whether ATP-binding cassette transporter 1 (ABCA1) R219K genetic variation is correlated with blood lipids.Specimens of peripheral blood were collected from 692 patients with cerebral apoplexy, aged 62 +/- aged 12, and 352 sex- and age-matched persons without cardio-cerebro-vascular disease. Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine the ABCA1 genotype: RR type (177 bp), RK type (177 bp, 107 bp, and 70 bp); and KK type (107 bp and 70 bp). The RR and KK type products were sequenced.The level of HDL-C showed an upward trend in the sequence of RR, RK, and KK genotypes with a significant difference between RR genotype (1.3 mmol/L +/- 0.4 mmol/L) and KK genotype (1.4 mmol/L +/- 0.4 mmol/L), especially in the males. The levels of TG tended downward in the sequence of RR, RK, and KK genotypes, however, without a significant difference between any 2 genotypes. Linear regression analysis showed that the HDL-C level was positively correlated with age in the noncarriers of ABCA1R219K genetic variation (RR genotype), and the TC level was negatively correlated with age in the carriers (RK + KK genotype). In the cohort aged
- Central South University China (People's Republic of)
- Second Xiangya Hospital of Central South University China (People's Republic of)
Male, Base Sequence, Genotype, Cholesterol, HDL, Molecular Sequence Data, Genetic Variation, Hyperlipidemias, Middle Aged, Polymorphism, Single Nucleotide, Cerebrovascular Disorders, Gene Frequency, Humans, ATP-Binding Cassette Transporters, Female, Polymorphism, Restriction Fragment Length, Triglycerides, ATP Binding Cassette Transporter 1, Aged
Male, Base Sequence, Genotype, Cholesterol, HDL, Molecular Sequence Data, Genetic Variation, Hyperlipidemias, Middle Aged, Polymorphism, Single Nucleotide, Cerebrovascular Disorders, Gene Frequency, Humans, ATP-Binding Cassette Transporters, Female, Polymorphism, Restriction Fragment Length, Triglycerides, ATP Binding Cassette Transporter 1, Aged
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