Untangling the web: mitochondrial fission and apoptosis.
Copyright policy )Untangling the web: mitochondrial fission and apoptosis.
Mitochondria exist as an interconnected network that is constantly remodeled by balancing membrane fission and fusion events. A new study by Szabadkai et al. in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis.
- Dana-Farber Cancer Institute United States
- Harvard University United States
- Brigham and Women's Faulkner Hospital United States
- Howard Hughes Medical Institute United States
Cell Membrane, Apoptosis, Protein Serine-Threonine Kinases, Endoplasmic Reticulum, Mitochondria, Death-Associated Protein Kinases, Imaging, Three-Dimensional, Microscopy, Fluorescence, Calcium-Calmodulin-Dependent Protein Kinases, Image Processing, Computer-Assisted, Humans, Calcium, Apoptosis Regulatory Proteins, HeLa Cells
Cell Membrane, Apoptosis, Protein Serine-Threonine Kinases, Endoplasmic Reticulum, Mitochondria, Death-Associated Protein Kinases, Imaging, Three-Dimensional, Microscopy, Fluorescence, Calcium-Calmodulin-Dependent Protein Kinases, Image Processing, Computer-Assisted, Humans, Calcium, Apoptosis Regulatory Proteins, HeLa Cells
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