New advancements in technological fields, continually has had a major impact on dental practice. The emergence of tissue engineering and biomimetic concepts has enhanced the predictability of existing therapy and also has radically recast approaches towards the dentoalveolar reconstruction. Tissue engineering in the simplest sense is a combination of material sciences and biology to repair tissues and organs which will unquestionably offer an exciting therapeutic alternative that have never been available before. This article is a brief introduction to the ever expanding field of tissue engineering and its possible implication in periodontal regeneration.