To explore the treatment of corneal perforation, lamellar corneal graft cetosina was performed in patients with corneal perforation by operation of eliminating foreign body in deep cornea.Five patients with operation of eliminating foreign body in deep cornea were treated with lamellar corneal graft certosina from 1999 to 2002. These five cases were all offered 1-week conservative therapy but without curative effect. The period of postoperative follow-up was 1 year.All five cases were healed, and attained satisfying anterior chamber. The inflammation of each anterior pole of eye was controlled quickly. The visual acuity was all improved quickly. The visual acuity was 0.15-1.0 (mean: 0.51) after one year follow-up. Slit-lamp examination showed translucence slight cloudy in the areas of corneal operation. The rest areas of cornea were transparent. No corneal neovascular and fore-and-aft iris conglutination appeared. There was no obvious change by the keratometer and corneal topography.Lamellar corneal graft certosina is an effective method for patients with corneal perforation due to operation of eliminating foreign body in deep cornea.