Acute lymphoblastic leukemia in infants.

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2004 Turkey English Publisher:Hacettepe University Institute of Child HealthJournal:The Turkish journal of pediatrics, volume 46 (issn: 0041-4301,

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Authors: Gumruk, FATMA; Hicsonmez, G; Tuncbilek, E; Tuncer, AM; Cetin, M; Yetgin, S; Gurgey, A;

pmid: 15214738

Acute lymphoblastic leukemia in infants.

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Abstract

Between January 1978 and August 1999, 29 infants with newly diagnosed acute lymphoblastic leukemia (ALL) were treated on three consecutive protocols. Eighteen patients with infant ALL diagnosed between 1978-1991 were included in Group 1. In this group, treatment comprised a two- or three-drug induction with prednisolone, vincristine and L-asparaginase, and maintenance therapy consisted of weekly oral administration of mercaptopurine and methotrexate for three years. Group 2: Between 1991 and 1999, 11 infants with ALL were treated by St. Jude Total Therapy XI (n=4) and XIII (n=7) protocols with minor modification. Three years' event-free survival (+/-SE) was 14 +/- 9% in group 1. In group 2, this rate was 25 +/- 22% in Total XI and 57 +/- 19% in Total XIII. Outcome for infants on protocols Total Therapy XI and XIII improved compared with that of group 1.

Country

Turkey

Related Organizations

Hacettepe University
Turkey

Keywords

Male, Prednisolone, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Pediatrics, Methylprednisolone, Survival Analysis, RJ1-570, Disease-Free Survival, Survival Rate, Treatment Outcome, Recurrence, Vincristine, Antineoplastic Combined Chemotherapy Protocols, Asparaginase, Humans, Female, Follow-Up Studies, Retrospective Studies

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