Due to the availability of factors whose reasons have not been studied so far for this area. Volgograd and Volgograd Region should be recognized to be a dirofilariasis-endemic zone. The lack of an actual system of prevention, as well as other objective and subjective factors are responsible for constantly increasing numbers of ill human beings and animals. The disease awaits further thorough studies to reveal the causes of this disease in the area; to elaborate a package of preventive measures, and to improve methods of diagnosis, surgical and medical treatments.