Alpha-synuclein aggregation.
Copyright policy )Alpha-synuclein aggregation.
Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.
- Queen's University Belfast United Kingdom
- University of Arkansas for Medical Sciences United States
570, Molecular Sequence Data, Synucleins, 610, Nerve Tissue Proteins, Parkinson Disease, Amyloidosis, alpha-Synuclein, Animals, Humans, Amino Acid Sequence, Protein Structure, Quaternary
570, Molecular Sequence Data, Synucleins, 610, Nerve Tissue Proteins, Parkinson Disease, Amyloidosis, alpha-Synuclein, Animals, Humans, Amino Acid Sequence, Protein Structure, Quaternary
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