This paper reported that acceleration of tooth movement can be gained by submucosal injection of some kind of medicine.To avoid the pain caused by the injection,conventional drug administration was ameliorated in this study by adopting the method of ionophoresis rabibits were divided into 2 groups and the standard otthodontic appliances were placed in the lower incisors of all animals.The 2 groups were separately recieved submucosal iontophoresis and injection of 0.9% NaCl which served as control.The result showed that animals with iontophoresis,in whose periodontal pression side more osteoclasts were observed histologically,had gained rapider tooth movement than those with injections.