
Pfizer (formerly Pharmacia), in collaboration with its wholly owned subsidiary Sensus, has developed and launched pegvisomant, a pegylated, genetically modified human growth hormone (hGH), for the treatment of acromegaly. Pegvisomant, in contrast to classical somatostatin analogs which lower hGH synthesis, exerts its anti-hGH action by preventing GH receptor activation. This drug is now available in the US and Europe for the treatment of acromegaly.
Structure-Activity Relationship, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Human Growth Hormone, Delayed-Action Preparations, Injections, Subcutaneous, Acromegaly, Animals, Humans, Receptors, Somatotropin
Structure-Activity Relationship, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Human Growth Hormone, Delayed-Action Preparations, Injections, Subcutaneous, Acromegaly, Animals, Humans, Receptors, Somatotropin
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