[The influence of craniotomy on cytokines and immunological function].

The purpose of the study is to elucidate the effects of a craniotomy on patients regarding the cytokines and immunological function. TNF-alpha, IL-6, the CD4/8 ratio, cortisol, and WBC were all measured perioperatively in 29 patients. No serum TNF-alpha was detectable in any patients. The IL-6 level, cortisol and neutrophils all showed an increase with a peak at three hours after the end of operation. On the other hand, the lymphocytes and the CD4/8 ratio demonstrated a opposite pattern with a negative peak at the same time, however, these levels all gradually recovered to their preoperative states on the 7th operative day. The overall effect of a craniotomy was therefore found to correlate with the length of the operation.

Related Organizations

Fukuoka University
Japan

Keywords

Adult, Aged, 80 and over, Male, Time Factors, Adolescent, Hydrocortisone, Brain Neoplasms, Interleukin-6, Tumor Necrosis Factor-alpha, Middle Aged, Cerebrovascular Disorders, Leukocyte Count, Stress, Physiological, Humans, Female, Hemifacial Spasm, Biomarkers, Craniotomy, Aged

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