The present review paper surveys published electromigration methods for the determination of active substances occurring in plant drugs officinal in CL 97. The review involves the electrophoretic methods (CZE) that were used for the separation of different natural compounds including flavonoids, phenolic glycosides, anthraglycosides, cardiac glycosides, alkaloids, organic acids, amino acids, polypeptides, and proteins. The advantages and drawbacks of CZE methods relative to corresponding HPLC techniques are also discussed.