[Endogenous hyperlactatemia and insulin secretion].

G, Ribes; G, Valette; F, Lignon; M M, Loubatières-Mariani

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Article . 1978

Data sources: Europe PubMed Central

[Endogenous hyperlactatemia and insulin secretion].

descriptionPublicationkeyboard_double_arrow_right Article 29 Nov 1978 French Journal:Comptes rendus des seances de la Societe de biologie et de ses filiales, volume 172 (issn: 0037-9026,

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Authors: G, Ribes; G, Valette; F, Lignon; M M, Loubatières-Mariani;

pmid: 150887

[Endogenous hyperlactatemia and insulin secretion].

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Abstract

In the normal anesthetized dog, the endogenous hyperlactatemia induced either by intense muscular work or by a high dose of phenformin (20 mg/kg subtucaneously) is followed by an increase in the pancreaticoduodenal insulin output. A previous perfusion of sodium dichloroacetate (50 mg/kg. h) opposes the hyperlactatemia, and reduces or suppresses the increase in insulin output.

Keywords

Kinetics, Dogs, Dichloroacetic Acid, Phenformin, Insulin Secretion, Physical Exertion, Lactates, Animals, Insulin

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