Alexithymia in Noonan syndrome.
Copyright policy )Alexithymia in Noonan syndrome.
Although Noonan syndrome is quite prevalent, there is a general paucity in the description of psychological and psychiatric aspects. In the present paper a 19-year-old female patient with Noonan syndrome is described who presented with anxiety symptoms. Mutation analysis in PTPN11, the NS1 gene on chromosome 12q24, showed no abnormalities. A diagnosis of panic disorder without agoraphobia was established. Treatment with citalopram resulted in a gradual decline of anxiety symptoms. The psychological profile was characterized by a prominent alexithymia. The main conclusion is that patients with Noonan syndrome might have deficits in emotional adaptative functions. It is hypothesized that alexithymia is a key feature of the behavioural phenotype.
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6 p.
- Radboud University Nijmegen Netherlands
- Erasmus University Rotterdam Netherlands
Adult, Chromosomes, Human, Pair 12, Noonan Syndrome, Citalopram, Experimental Psychopathology and Treatment, Humans, Panic Disorder, EMC OR-01-58-01, Abnormalities, Multiple, Female, Affective Symptoms, Agoraphobia, Selective Serotonin Reuptake Inhibitors
Adult, Chromosomes, Human, Pair 12, Noonan Syndrome, Citalopram, Experimental Psychopathology and Treatment, Humans, Panic Disorder, EMC OR-01-58-01, Abnormalities, Multiple, Female, Affective Symptoms, Agoraphobia, Selective Serotonin Reuptake Inhibitors
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