[Clinical pharmacology and efficacy of meropenem].

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1992 Japanese Publisher:Japan Antibiotics Research AssociationJournal:The Japanese journal of antibiotics, volume 45 (issn: 0368-2781,

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Authors: TSUTSUMI, HIROYUKI; CHIBA, SHUNZO;

pmid: 1507403

[Clinical pharmacology and efficacy of meropenem].

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Abstract

We studied a newly developed carbapenem, meropenem (MEPM), and obtained the following results. 1. Pharmacokinetics of MEPM in pediatrics was examined in 3 patients. MEPM was injected intravenously at a dose of 16-22 mg/kg by drip infusion for 30 minutes, and its concentrations in serum and urine were determined using bioassay. The average peak value of serum levels of MEPM was 38.4 micrograms/ml and T1/2 beta of MEPM was 1.26 hours. The urinary recovery rate for the first 6 hours after administration was 65.6%. 2. Clinical evaluations of MEPM in pediatrics were done in 14 patients with ages ranging, 1 month to 14 years, with various bacterial infections. Excellent or good clinical responses were observed in all patients, and bacteriological eradication were obtained in 7 out of 8 cases. No serious side effects were observed in any cases, but 2 showed mild and transient GOT, GPT elevations.

Keywords

Male, Adolescent, Enterobacteriaceae Infections, Infant, Bacterial Infections, Meropenem, Staphylococcal Infections, Citrobacter freundii, Child, Preschool, Staphylococcus epidermidis, Humans, Female, Pseudomonas Infections, Thienamycins, Child

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