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Article
Data sources: CORE (RIOXX-UK Aggregator)
Cell
Article . 2004
Data sources: Europe PubMed Central
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Dicers at RISC; the mechanism of RNAi.

descriptionPublicationkeyboard_double_arrow_right Article 06 May 2004 English Publisher:Cell Press.Journal:Cell, volume 117 (issn: 0092-8674, Copyright policy )
Authors: Tijsterman, Marcel; Plasterk, Ronald H.A;

pmid: 15066275

Dicers at RISC; the mechanism of RNAi.

Abstract

The pathway of RNA interference starts when Dicer cuts dsRNA into small interfering RNAs (siRNAs) that subsequently target homologous mRNAs for destruction. microRNA processing from stem loop precursors similarly requires Dicer activity. Two papers in this issue of Cell now demonstrate that Dicer is also essential for the execution phase of RNAi and explore the distinct requirements for Dicers in the siRNA and miRNA pathways.

Keywords

Ribonuclease III, MicroRNAs, Drosophila melanogaster, Animals, Humans, RNA Interference, RNA, Messenger, RNA, Small Interfering, RNA, Double-Stranded

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    popularity
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    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
244
Top 1%
Top 1%
Top 1%