Reaction of 7-hydroxy-4-methyl coumarin with amido/imido alcohols in ethanol containing concentrated hydrochloric acid afforded 8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-coumarins (1a-f). Interaction of 1a-f with hydrazine hydrate in pyridine resulted in 1-amino-8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolines (2a-f). Treatment of 2 with formaldehyde in ethanol resulted in 1,3,5-tris-(8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)-2,4,6-hexahydro-s-triazines (3a-c). Antiviral activity of compounds 2a-d and 3a, 3b upon Japanese encephalitis virus (JEV) and Herpes simplex virus-1 (HSV-1) was evaluated on vero cells in vitro. 3a-c were also screened for their antihypertensive activity.

Reakcijom 7-hidroksi-4-metilkumarina s amido/imido alkoholima u etanolu s koncentriranom kiselinom pripravljeni su 8-aralkil amido/imido-alkil-7-hidroksi-4-metilkumarini (1a-f). Ti spojevi su s hidrazin hidratom u piridinu dali 1-amino-8-aralkil amido/imido-alkil-7-hidroksi-4-metil-2-okso-kinoline (2a-f). Iz spojeva 2 i formaldehida u alkoholnoj otopini sintetizirani su 1,3,5-tris-(8-aralkil amido/imido-alkil-7-hidroksi-4-metil-2-okso-kinolinil)-2,4,6-heksahidro-s-triazini (3a-c). Antiviralno djelovanje spojeva 2a-d, 3a i 3b testirano je na Japanese encephalitis virus (JEV) i Herpes simplex virus-1 (HSV-1) na vero stanicama in vitro. Osim toga ispitano je antihipertenzivno djelovanje produkata 3a-c.