The paper presents two cases of infection with Strongyloides stercoralis (in a 13-year-old boy and in a 93-year-old female), occurred in the Moscow Region, which is indicative of the resurgence of stronglyoidiasis in the Moscow Region. Although the likelihood of this infection in this region is little, nevertheless, strongyloidiasis should be borne in mind in examining patients who are not leaving for well-known endemic areas if they have an allergic reaction of unclear etiology, eosinophilia, and digestive disorders. In these cases, the syndromic-and-empiric approach to justifying and performing chemotherapy is recommended due to the inadequate efficiency of parasitological methods for diagnosing strongyloidiasis at the low rate of invasion. These cases are indicative of the rather low virulence of Moscow strains, but at the same time of their capacity for autoinvasion and accordingly for the long-term infection of patients without recurrent infections.