[Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].

Xiao-hong, Zhao; Di-hua, Chen; Jian-yong, Si; Rui-le, Pan; Lian-gang, Shen; Duo, Chen

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China Journal of Chi...arrow_drop_down

China Journal of Chinese Materia Medica

Article . 2004

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[Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].

descriptionPublicationkeyboard_double_arrow_right Article 22 Jun 2004Journal:Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, volume 28 (issn: 1001-5302,

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Authors: Xiao-hong, Zhao; Di-hua, Chen; Jian-yong, Si; Rui-le, Pan; Lian-gang, Shen; Duo, Chen;

pmid: 15015286

[Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].

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Abstract

To find new active constituents from Rhizome of Cimicifuga foetida.Various column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences.Four triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4).Compound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.

Related Organizations

Chinese Academy of Medical Sciences & Peking Union Medical College
China (People's Republic of)

Keywords

Cimicifuga, Plants, Medicinal, Molecular Structure, Bone Neoplasms, Triterpenes, Rats, Lanosterol, Cell Line, Tumor, Animals, Osteoblastoma, Cell Division, Rhizome

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