Invasive and non-invasive measurements were used to evaluate methods of correcting oxygen consumption and extraction within the local circulation in bedrested human subjects. For the first time demonstrated was the vanity of attempts to improve O2 supply to the human peripheral tissues by re-establishment of the circulating blood volume and increasing oxygen content in the affluent blood. The reason can be that HD bed rest impacts the ability of peripheral tissues to augment consumption of the surplus oxygen. The experiment showed that preliminary infusion of an antihypoxant (gamma-hydroxibutyric acid) recovers this ability even in case of abundant oxygen. Based on results of the investigation, oxygen supply correction can be considered as a way to improve (when necessary) oxygen supply to the human peripheral tissues during HD bed rest.