[Pharmacokinetics and pharmacodynamics of matrine and oxymatrine].
Copyright policy )[Pharmacokinetics and pharmacodynamics of matrine and oxymatrine].
On measuring the percentage of QTc interval prolongation, the pharmacokinetic and pharmacodynamic profiles of i.v. matrine or oxymatrine in rabbits were analyzed by combined pharmacokinetic and pharmacodynamic model. The plasma concentration--time profiles of the two drugs can be described by a two--compartment open model, and the relationship between effect and effect compartment concentration of both drugs can be represented by the sigmoid Emax model. Marked differences in pharmacokinetic and pharmacodynamic parameters between the two drugs were found, but their pharmacokinetic and pharmacodynamic properties were dose--independent in the dose ranges used in the experiment.
- China Pharmaceutical University China (People's Republic of)
Male, Alkaloids, Animals, Female, Rabbits, Matrines, Quinolizines
Male, Alkaloids, Animals, Female, Rabbits, Matrines, Quinolizines
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!