A frequency of VIN and vulvar carcinoma is continuously increasing, especially in young women in whom the changes are often multifocal.Evaluation of VIN and vulvar carcinoma coexistence with intraepithelial as well as invasive changes within vagina and uterine cervix and estimation of the frequency of HPV infection accompanying these changes.Study group was consisted of 389 women aged 22-92 y. Cytologic, colposcopic examinations of the entire low genital tract and diagnosis of HPV infection with use of DNA HPV hybridization technique were performed in all cases. There were 148 (38.0%) cases of vulvar changes in women below 45 yrs of life, and 241 (62.0%) cases in older patients. HPV infection was diagnosed in 91 (61.5%) young women and in 41 (17.0%) women over 45 yrs. Intraepithelial neoplasia or invasive cancer of vagina and/or uterine cervix were diagnosed in 16 (10.8%) cases of young patients, and HPV infection of high oncological potential was diagnosed in 13 (81.3%) of these patients.There is a high percent of coexistence of intraepithelial as well as invasive changes of the vulva, vagina and uterine cervix which mostly coexist with HPV infection of high oncological potential. These data suggest an important role of HPV infection in low female genital tract carcinogenesis and obliges to a precise examination of the entire low female genital tract, especially in young women.