The objective of this retrospective study was to compare skeletal and dental arch morphology of children with posterior crossbites with a control group of children without posterior crossbites. The study included 93 patients with a posterior crossbite (33 boys and 60 girls) and 97 patients without a posterior crossbite (50 boys and 47 girls). Skeletal and dental characteristics between the two groups were compared using measurements of dental casts, and lateral and posteroanterior cephalograms. Univariate analyses revealed that seven characteristics were significantly different between the crossbite and non-crossbite groups: mandibular plane angle, lower face height, skeletal maxillary to mandibular width ratio, maxillary intermolar width, mandibular intermolar width, maxillary to mandibular intermolar width ratio, and mandibular unit length. Using maxillary to madibular intermolar width ratio as the outcome measure, a stepwise variable selection technique, analyzed all 190 patients and found only two variables significantly associated with this measure: skeletal maxillary to mandibular width ratio and lower face height. The coefficient of multiple determination for this model was only 13%, indicating that these two variables accounted for only a small portion in the variation of the ratio between the maxillary and mandibular intermolar widths.