[Expression and clinical significance of VEGF-C mRNA and CD 31 in esophageal squamous cell carcinoma].
Copyright policy )[Expression and clinical significance of VEGF-C mRNA and CD 31 in esophageal squamous cell carcinoma].
To investigate the expression of vascular endothelial growth factor-C (VEGF-C) mRNA and CD 31 in esophageal squamous cell carcinoma (ESCC) and its promotion of lymphatic metastasis. The expression of VEGF-C mRNA was examined in 43 ESCC by in situ hybridization. Intratumoral microvessel density (MVD) was assessed by immunostaining endothelial cells, using anti-CD31 antibody. The positive rate of VEGF-C mRNA expression was 41.86%. The average rank of MVD was 76.36 +/- 20.30/mm2. VEGF-C mRNA expression correlated significantly with lymph node metastasis, TNM stage and depth of invasion (p 0.05). MVD correlated significantly with lymph node metastasis and TNM stage (p 0.05). MVD was significant higher in the VEGF-C positive tumors than negative tumors (p < 0.05). The present study indicated that VEGF-C might play a role in lympatic metastasis via lymphangiogenesis and angiogenesis in ESCC.
- National Academy of Sciences of Ukraine Ukraine
- Zhejiang Ocean University China (People's Republic of)
- Institute of Cell Biology Ukraine
Male, Esophageal Neoplasms, Neovascularization, Pathologic, Microcirculation, Vascular Endothelial Growth Factor C, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1, Lymphatic Metastasis, Carcinoma, Squamous Cell, Humans, Female, Neoplasm Invasiveness, RNA, Messenger, Aged, Neoplasm Staging
Male, Esophageal Neoplasms, Neovascularization, Pathologic, Microcirculation, Vascular Endothelial Growth Factor C, Middle Aged, Platelet Endothelial Cell Adhesion Molecule-1, Lymphatic Metastasis, Carcinoma, Squamous Cell, Humans, Female, Neoplasm Invasiveness, RNA, Messenger, Aged, Neoplasm Staging
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