Neurological Soft Signs (NSS) are defined as potential biological markers for schizophrenic disorders. There has recently been a renewer interest in its study. These NSS are not related to localized brain lesions, but it has been hypothesized that they reflect abnormalities in motor, sensory and integrative functions. It has been reported that schizophrenic patients exhibit NSS years before of the onset of psychotic symptoms and that they remain after recovery of that symptoms. Environmental and genetic causes have been involved in their origin. Different assessment scales have been developed in order to allow for comparisons between different studies and for relating NSS to clinical, psychopathological, neurocognitive, social and demographical variables of the disease. It has been demonstrated their relative independence of treatment and evolution of the disease.