Direct membrane damage and miconazole lethality.

W H, Beggs

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Article . 1992

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Direct membrane damage and miconazole lethality.

descriptionPublicationkeyboard_double_arrow_right Article 27 Nov 1992 English Journal:Research communications in chemical pathology and pharmacology, volume 77 (issn: 0034-5164,

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Authors: W H, Beggs;

pmid: 1439193

Direct membrane damage and miconazole lethality.

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Abstract

Physicochemical membrane damage is presumably the cause of growth phase-dependent lethal miconazole action. In support of this, we showed that as stationary phase inoculum cells of Candida albicans progress into early logarithmic phase, susceptibilities to lethal action and to miconazole-induced release of K+ increase together.

Keywords

Miconazole, Candida albicans, Cell Cycle, Cell Membrane, Potassium, Growth Inhibitors

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