Hypercalciuria is the cause of almost 20% of all secondary osteoporoses and in 23% these cases are associated with calcium urolithiasis. It is therefore necessary to search for these patients actively because their treatment with hydrochlorothiazide and amiloride is easy and highly effective. We must not be satisfied with the finding of hypercalciuria as the only cause of demineralization of bone, as several causes may combine in a single patient. Comprehensive treatment of osteopenia associated with hypercalciuria is relatively shorter and more successful than in other forms of secondary osteopenias.