Quinolinehydrazones as inhibitors of retroviral reverse transcriptase.
Copyright policy )Quinolinehydrazones as inhibitors of retroviral reverse transcriptase.
The inhibitory activity of a series of 2- and 4-quinolinehydrazones on retroviral reverse transcriptase has been studied on enzymes from M-MuLV, RAV-2, and on a crude lysate of HIV-1, assuming the first two enzymes as potential models of the third. The highest activity is mainly found in lipophilic, water soluble 4-quinolinehydrazones. The inhibitory activity of these compounds decreases in changing from the M-MuLV to the RAV-2, and HIV-1 enzymes, in this order.
Retroviridae, Chemical Phenomena, Cell Survival, Chemistry, Physical, Hydrazones, Quinolines, Reverse Transcriptase Inhibitors, Cell Survival; Chemistry, Physical; Hydrazones; Quinolines; Retroviridae; Reverse Transcriptase Inhibitors
Retroviridae, Chemical Phenomena, Cell Survival, Chemistry, Physical, Hydrazones, Quinolines, Reverse Transcriptase Inhibitors, Cell Survival; Chemistry, Physical; Hydrazones; Quinolines; Retroviridae; Reverse Transcriptase Inhibitors
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