One individual with two or three malignant neoplasms is not uncommon. However, a patient with more than 5 primary malignancies is unusual. We present a 51-year-old female who developed 6 metachronous primary malignant neoplasms in a period of 10 years. The anatomic sites of neoplasms in this patient included the cervix, larynx, skin, left breast, bladder and right lung (middle lobe). All of the tumors were proven by pathologic examination, and each of these tumors was recognized as a distinct primary tumor. Aggressive surgical resection, post-operative irradiation and chemotherapy showed good response in this patient. This patient had no familial or hereditary tendencies but, definite impairment of the cellular immunity had been identified.