During the last year we came across three cases of Acanthamoeba keratitis. They were all contact lens wearers. The diagnosis of Acanthamoeba keratitis was established by the history, clinical picture and the culture of corneal and conjunctival swabs. The patients were treated with metronidazole (Flagyl) 0.5% eyedrops, propamidine isethionate (Brolene) 0.1% eyedrops, Neomycin eyedrops, topical corticosteroids, mydriatics and beta-blockers. One tablet or itraconazole (Sporanox) a day was given orally. Infection subsided in two patients. The third patient still suffers from recurrent corneal erosions and shows a pronounced corneal immune reaction.