
Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F1 mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectivity of larvae.
Male, Muscles, Mice, Inbred Strains, Trichinellosis, Albendazole, Mice, Animals, Intestinal Diseases, Parasitic, Trichinella spiralis
Male, Muscles, Mice, Inbred Strains, Trichinellosis, Albendazole, Mice, Animals, Intestinal Diseases, Parasitic, Trichinella spiralis
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