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Efficacy of albendazole against Trichinella pseudospiralis and Trichinella spiralis in mice.

Authors: J, Bany; J, Lach; Z, Golińska;

Efficacy of albendazole against Trichinella pseudospiralis and Trichinella spiralis in mice.

Abstract

Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F1 mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectivity of larvae.

Keywords

Male, Muscles, Mice, Inbred Strains, Trichinellosis, Albendazole, Mice, Animals, Intestinal Diseases, Parasitic, Trichinella spiralis

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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