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Russian Clinical Laboratory Diagnostics

Article . 2003

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[Immunoenzyme technique for analysis of cystatin C in serum of patients with hemoblastosis].

descriptionPublicationkeyboard_double_arrow_right Article 16 Sep 2003 Russian Journal:Klinicheskaia laboratornaia diagnostika (issn: 0869-2084,

Authors: O N, Poteriaeva; T A, Usova; O A, Levina; E S, Iarygina; T A, Korolenko;

pmid: 12934331

[Immunoenzyme technique for analysis of cystatin C in serum of patients with hemoblastosis].

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Abstract

Cystatin C is a low-molecular endogenous inhibitor of cysteic proteinases. Sets for immune-enzyme assay of cystatin C in human blood serum (KRKK, Slovenia) were made used of in the case study. The concentration of cystatin C (CCC) in blood serum was found to be higher in cases of certain hemoblastoses (Non-Hodgkin's disease, lymphogranulomatosis and multiple myeloma), with the highest concentration of the inhibitor being observed in patients with resistance to the conducted polychemotherapy and a poor prognostication. The treatment of Non-Hodgkin's disease and of lymphogranulomatosis brought about a normalized CCC in blood serum. It was suggested that CCC in blood serum reflects a nature of tumor growth and, obviously, it can be a criterion in assessing the therapy efficiency. The concentration of alpha 1-proteinases inhibitor remained unchanged before and after treatment.

Keywords

Adult, Leukemia, Lymphoma, Non-Hodgkin, Adrenal Gland Diseases, Cystatins, Hodgkin Disease, Immunoenzyme Techniques, Treatment Outcome, Drug Resistance, Neoplasm, Hematologic Neoplasms, Acute Disease, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Humans, Cystatin C, Multiple Myeloma

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