A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase.

Raef, Ahmed; Finian J, Leeper

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Organic & Biomolecular Chemistry

Article . 2004

Data sources: Europe PubMed Central

A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase.

descriptionPublicationkeyboard_double_arrow_right Article 12 Jan 2004 English Journal:Organic & biomolecular chemistry, volume 1 (issn: 1477-0520,

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Authors: Raef, Ahmed; Finian J, Leeper;

pmid: 12929382

A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase.

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Abstract

Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (Ki = 3 microM).

Keywords

Hydroxymethylbilane Synthase, Kinetics, Models, Chemical, Porphobilinogen, Enzyme Inhibitors, Chromatography, High Pressure Liquid

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