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Acta Poloniae Pharmaceutica
Article . 2003
Data sources: Europe PubMed Central
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Kinetics of diltiazem hydrochloride in solid phase.

descriptionPublicationkeyboard_double_arrow_right Article 12 Aug 2003 English Journal:Acta poloniae pharmaceutica, volume 60 (issn: 0001-6837, Copyright policy )
Authors: Izabela, Muszalska; Maciej, Siakowski;

pmid: 12848364

Kinetics of diltiazem hydrochloride in solid phase.

Abstract

The influence of temperature (353, 358, 363, 368, and 373 K) and relative humidity (76.4, 66.5, 60.5 and 50.9% RH) on the stability of diltiazem hydrochloride in the solid phase was investigated. The decomposition was followed by a HPLC method with UV detection. The kinetic (rate constants, t0.1 and t0.5) and thermodynamic parameters (energy, entalpy and entropy of activation) of the degradation of diltiazem hydrochloride were calculated.

Keywords

Diltiazem, Kinetics, Drug Stability, Thermodynamics, Humidity, Indicators and Reagents, Spectrophotometry, Ultraviolet, Calcium Channel Blockers, Algorithms, Chromatography, High Pressure Liquid

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold