Inhibition of mite protease (Df-protease) with protease inhibitors.
Copyright policy )Inhibition of mite protease (Df-protease) with protease inhibitors.
A protease from house dust mite(Dermatophagoides farinae) having high specificity towards a substrate of blood coagulation factor XIIa catalyzes the activation of kallikrein-kinin system in plasma (Takahashi et al., 1990). To prevent the formation of kinin by the mite-protease, inhibition of the protease with its inhibitors was tested in vitro and in vivo. Its kinetic studies revealed that Ki values are 3.9 x 10(-10) M for aprotinin, 3.0 x 10(-9) M for soybean trypsin inhibitor (Kunitz) and 2.5 x 10(-8) M for gabexate mesylate. Enhancement of blood permeability in guinea pigs caused by the protease was markedly suppressed by these inhibitors.
Mites, Gabexate, Kallikrein-Kinin System, Guinea Pigs, Factor XIIa, Binding, Competitive, Substrate Specificity, Capillary Permeability, Kinetics, Aprotinin, Endopeptidases, Animals, Kallikreins, Protease Inhibitors, Trypsin Inhibitor, Kunitz Soybean, Skin
Mites, Gabexate, Kallikrein-Kinin System, Guinea Pigs, Factor XIIa, Binding, Competitive, Substrate Specificity, Capillary Permeability, Kinetics, Aprotinin, Endopeptidases, Animals, Kallikreins, Protease Inhibitors, Trypsin Inhibitor, Kunitz Soybean, Skin
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