[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin].

N A, Gorenkova; I V, Nazarenko; I V, Samorukova; M Sh, Avrushchenko; A V, Volkov

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Anesteziologiya i Reanimatologiya

Article . 2003

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[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin].

descriptionPublicationkeyboard_double_arrow_right Article 16 Jun 2003 Russian Journal:Anesteziologiia i reanimatologiia (issn: 0201-7563,

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Authors: N A, Gorenkova; I V, Nazarenko; I V, Samorukova; M Sh, Avrushchenko; A V, Volkov;

pmid: 12611163

[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin].

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Abstract

A complex of behavioral tests revealed diminished anxiety, increased locomotor and exploratory activities, and changes in different learning tests in resuscitated animals. Mexidol alone and in combination with kyotorphin exhibited antistressogenic and nootropic activities, and led to a compensation of ischemic lesions in rats. It can be stated that a the injection of mexidol in combination with kyotorphin yielded better results due to its neuroprotective effect in the CA1 and CA4 fields of the hippocampus.

Keywords

Male, Psychotropic Drugs, Behavior, Animal, Mental Disorders, Cardiopulmonary Resuscitation, Heart Arrest, Rats, Picolines, Animals, Drug Therapy, Combination, Endorphins

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