WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.
Copyright policy )WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer.
WWOX (WW domain containing oxidoreductase), a putative tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1, is altered in breast, esophageal, and ovarian cancer. Because the FRA3B/FHIT locus at 3p14.2 is a preferential target for genetic changes caused by tobacco smoke, we intended to evaluate the status of the FRA16D/WWOX gene in non-small cell lung cancer; we have analyzed 27 paired normal and tumor lung tissues and 8 lung cancer cell lines for WWOX alterations by reverse transcriptase-PCR, loss of heterozygosity, and mutation analysis. Transcripts missing WWOX exons were detected in 7 primary tumors (7 of 27; 25.9%) and 5 of 8 cell lines. In addition, loss of heterozygosity at the WWOX locus was observed in 10 primary tumors (10 of 27; 37.0%). We conclude that WWOX alterations occur in a significant fraction of lung cancers and may contribute to the pathogenesis of non-small cell lung cancer.
- Thomas Jefferson University United States
- Kimmel Cancer Center United States
- University of Ferrara Italy
Lung Neoplasms, Loss of Heterozygosity, Neoplasm Proteins, Protein Structure, Tertiary, Carcinoma, Non-Small-Cell Lung, Tumor Cells, Cultured, Humans, Point Mutation, Genes, Tumor Suppressor, RNA, Messenger, Carrier Proteins, Oxidoreductases, Gene Deletion
Lung Neoplasms, Loss of Heterozygosity, Neoplasm Proteins, Protein Structure, Tertiary, Carcinoma, Non-Small-Cell Lung, Tumor Cells, Cultured, Humans, Point Mutation, Genes, Tumor Suppressor, RNA, Messenger, Carrier Proteins, Oxidoreductases, Gene Deletion
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