[Autoantibodies to the heterogeneous nuclear ribonucleoproteins and the autoimmune diseases].

L, Yang; M, Yu; C, Yang

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Article . 2003

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[Autoantibodies to the heterogeneous nuclear ribonucleoproteins and the autoimmune diseases].

descriptionPublicationkeyboard_double_arrow_right Article 07 Oct 2003Journal:Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, volume 21 (issn: 1000-503X,

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Authors: L, Yang; M, Yu; C, Yang;

pmid: 12567457

[Autoantibodies to the heterogeneous nuclear ribonucleoproteins and the autoimmune diseases].

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Abstract

Autoantibodies to the heterogeneous nuclear ribonucleoproteins (hnRNP) have a great role in the diagnosis of rheumatic diseases. hnRNP-A/B proteins are the main autoantigens in Rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD). Anti-RA33 autoantibodies which target the hnRNP proteins A2, B1, B2 (the 'RA33 complex') help to the diagnosis of RA at early stage. Therefore, anti-hnRNP autoantibodies are not only valuable diagnostic markers but may also allow deep insights into the pathogenetic mechanisms of rheumatic diseases.

Related Organizations

Malabar Medical College Hospital and Research Centre
India

Keywords

Arthritis, Rheumatoid, Humans, Lupus Erythematosus, Systemic, Biomarkers, Heterogeneous-Nuclear Ribonucleoproteins, Autoantibodies, Autoimmune Diseases, Mixed Connective Tissue Disease

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