[Cardioprotective effect of exogenous phosphocreatine in patients undergoing open heart surgery].

S X, Cheng; Q H, Hu

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Article . 2003

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[Cardioprotective effect of exogenous phosphocreatine in patients undergoing open heart surgery].

descriptionPublicationkeyboard_double_arrow_right Article 18 Jun 2003Journal:Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, volume 26 (issn: 1000-5625,

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Authors: S X, Cheng; Q H, Hu;

pmid: 12536735

[Cardioprotective effect of exogenous phosphocreatine in patients undergoing open heart surgery].

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Abstract

Twenty patients with rheumatic heart valve disease undergoing valve replacement were randomly divided into 2 group (n = 10): phosphocratine (neoton) group (group CP) in which 4.0 g neoton was used intravenously 2 days before operation and control group (group C) in which 5% G. S instead of neoton. The results showed that spontaneous recovery rate of heart beat in group CP was significantly higher than that in group C; requirement of inotropic drugs, serum MDA value and ultrastructural changes of myocardium were less in group CP than those in group C. There were no differences in release of myocardial enzymes and myocardial ATP content between 2 groups. It is suggested that neoton is an effective cardioprotective drug.

Related Organizations

Central South University
China (People's Republic of)

Keywords

Heart Valve Prosthesis Implantation, Cardiopulmonary Bypass, Cardiotonic Agents, Phosphocreatine, Superoxide Dismutase, Myocardium, Rheumatic Heart Disease, Humans

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