[Studies on the metabolism of gentiopicroside by rat intestinal flora].
Copyright policy )[Studies on the metabolism of gentiopicroside by rat intestinal flora].
To study the metabolism of gentiopicroside by rat intestinal flora in vitro and time profiles of gentiopicroside and its metabolites in rat serum after oral administration of gentiopicroside.Using high performance liquid chromatography (HPLC) for determination of gentiopicroside, gentianine and gentianal content of rat intestinal flora culture medium in vitro and rat serum sample in vivo.Gentiopicroside was metabolized quickly in vitro by rat intestinal flora, consequently gentianine and gentianal content appeared. Gentianine and gentianal were observed after gentiopicroside oral administration 4 times in rat serum sample, and gentiopicroside content decreased after oral administration 6 times.Gentianine and gentianal were the important bioactive metabolites of gentiopicroside in rats.
- Shanghai University of Traditional Chinese Medicine China (People's Republic of)
Male, Iridoid Glucosides, Rats, Intestines, Alkaloids, Glucosides, Animals, Iridoids, Gentiana, Rats, Wistar, Chromatography, High Pressure Liquid, Pyrans
Male, Iridoid Glucosides, Rats, Intestines, Alkaloids, Glucosides, Animals, Iridoids, Gentiana, Rats, Wistar, Chromatography, High Pressure Liquid, Pyrans
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