[Research on the transformation of ginsenoside Rg1 by intestinal flora].
Copyright policy )[Research on the transformation of ginsenoside Rg1 by intestinal flora].
The decomposition of Ginsenoside Rg1(Rg1) by intestinal bacteria in rats or human was investigated both in vitro and in vivo.The decompositions were investigated by means of thin-layer chromatography and Electron spurt ion mass.It was found that Rg1 was converted into two metabolites [Rh1 and 20(S)-protopanaxatriol(20S-Ppt)] by human intestinal bacteria in vitro, while three compounds [Rh1, F1, and 20(S)-Ppt] were detected in rat intestinal bacteria metabolism in vitro and in vivo.The decomposition and/or metabolism of Rg1 in rat and human digestive tract was confirmed. The mode of metabolism in rat is Rg1-->Rh1(F1)-->Ppt, while in human it is Rg1-->Rh1-->Ppt.
- Changchun University of Chinese Medicine China (People's Republic of)
Intestines, Male, Ginsenosides, Animals, Humans, In Vitro Techniques, Rats, Wistar, Bacterial Physiological Phenomena, Rats
Intestines, Male, Ginsenosides, Animals, Humans, In Vitro Techniques, Rats, Wistar, Bacterial Physiological Phenomena, Rats
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