[Domoic acid and glutamate receptors].

X, Chen; C, Wang

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Article . 2003

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[Domoic acid and glutamate receptors].

descriptionPublicationkeyboard_double_arrow_right Article 04 Apr 2003Journal:Wei sheng yan jiu = Journal of hygiene research, volume 29 (issn: 1000-8020,

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Authors: X, Chen; C, Wang;

pmid: 12520936

[Domoic acid and glutamate receptors].

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Abstract

Domoic acid is a kind of neurotoxin produced by diatoms and accumulated in food chain, which is harmful to the human health. The N-methyl-D-aspartate receptor and kainic acid/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor could be activated by domoic acid. The concentration of the intracellular Ca2+ could be elevated, causing a series of physiological and biochemical changes. The possible mechanisms of neurotoxicity induced by domoic acid through glutamate receptors are discussed.

Keywords

Kainic Acid, Neurotoxins, Animals, Humans, Receptors, AMPA, Kainic Acid Receptors, Receptors, N-Methyl-D-Aspartate

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