Growth hormone-releasing hormone and pituitary somatotrope proliferation.
Copyright policy )Growth hormone-releasing hormone and pituitary somatotrope proliferation.
Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH secretion and/or action result in dysregulated somatotrope proliferation, leading to hyperplasia and neoplastic transformation. Our understanding of the molecular and morphologic bases for these effects from both animal and clinical studies has greatly increased during the past decade. However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis.
- University of Illinois at Chicago United States
Mice, Knockout, Models, Molecular, Hypothalamo-Hypophyseal System, Hyperplasia, Human Growth Hormone, Molecular Sequence Data, Genetic Diseases, Inborn, Growth Hormone-Releasing Hormone, Mice, Mutant Strains, Paraneoplastic Endocrine Syndromes, Animals, Genetically Modified, Mice, Neuroendocrine Tumors, Gene Expression Regulation, Mutation, GTP-Binding Protein alpha Subunits, Gs, Animals, Humans, Amino Acid Sequence, Cell Division
Mice, Knockout, Models, Molecular, Hypothalamo-Hypophyseal System, Hyperplasia, Human Growth Hormone, Molecular Sequence Data, Genetic Diseases, Inborn, Growth Hormone-Releasing Hormone, Mice, Mutant Strains, Paraneoplastic Endocrine Syndromes, Animals, Genetically Modified, Mice, Neuroendocrine Tumors, Gene Expression Regulation, Mutation, GTP-Binding Protein alpha Subunits, Gs, Animals, Humans, Amino Acid Sequence, Cell Division
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