[Preclinical research--toxicology].
Copyright policy )[Preclinical research--toxicology].
The different steps of the toxicological testing of new drugs are shortly described. Furthermore it is discussed that only 60-70% of the drug induced adverse reactions in man can be predicted by the experimental methods being available at present. Special problems exist in evaluating the results of reproductive-toxicological, carcinogenicity and mutagenicity tests. These problems are illustrated by some experimental and clinical examples.
Chromosome Aberrations, Male, Time Factors, Reproduction, Research, Drug Evaluation, Preclinical, Embryo, Mammalian, Toxicology, Chromosomes, Rats, Mice, Dogs, Teratogens, Pregnancy, Carcinogens, Animals, Female, Mutagens
Chromosome Aberrations, Male, Time Factors, Reproduction, Research, Drug Evaluation, Preclinical, Embryo, Mammalian, Toxicology, Chromosomes, Rats, Mice, Dogs, Teratogens, Pregnancy, Carcinogens, Animals, Female, Mutagens
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