Conjugate vaccines extend the vaccinal prevention for children to more diseases. Conjugating the capsular polysaccharide to a carrier protein transforms a T-independent antigen in a T-dependent, allowing protection of the children (before 2 years of age) against Haemophilus influenzae type b, meningococcal C and pneumococcal infections. This article reviews the 3 conjugate vaccines and their results with focus on some questions: antigens interference in the immunological response, serological subrogate for protection, herd immunity and replacement of circulating serotypes.

Related Organizations

University of Kinshasa
Congo (Democratic Republic of)
Ecole de santé publique de Kinshasa
Congo (Democratic Republic of)

Keywords

Adult, Immunity, Cellular, Antigens, Bacterial, Vaccines, Conjugate, Haemophilus Infections, Haemophilus influenzae type b, Infant, Haemophilus influenzae, Pneumococcal Infections, Meningococcal Infections, Immunoglobulin G, Antibody Formation, Bacterial Vaccines, Humans, Vaccines, Combined

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