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Article . 2002
Data sources: Europe PubMed Central
Claim

[The effect of Kagocel on herpes virus reproduction].

descriptionPublicationkeyboard_double_arrow_right Article 27 Nov 2002 Russian Journal:Voprosy virusologii, volume 47 (issn: 0507-4088, Copyright policy )
Authors: G A, Galegov; A N, Narovlianskiĭ; A A, Sarymsakov; M V, Mezentseva; V O, Polonskiĭ; L A, Gomes; V G, Nesterenko; +1 Authors

pmid: 12271726

[The effect of Kagocel on herpes virus reproduction].

Abstract

The effect of an original drug Kagocel on the reproduction of Herpes simplex virus including its mutant strains resistant to basic antiherpetic medicine Acyclovir was evaluated. Kagocel was shown to have a low cytotoxic effect on Vero cell and inhibited reproduction of Herpes virus type 1 and Herpes virus type 2 in noncytotoxic concentrations. Kagocel was also demonstrated to inhibit the reproduction of Herpes virus type 1, resistant to combination of Acyclovir and phosphonoacetic acid. Detection of direct antiherpetic activity of Kagocel in vitro opens good perspectives to its clinical application, especially in combination with Acyclovir, the medication with other antiherpetic mechanism of action.

Keywords

Phosphonoacetic Acid, Dose-Response Relationship, Drug, Herpesvirus 2, Human, Gossypol, Acyclovir, Herpesvirus 1, Human, Antiviral Agents, Chlorocebus aethiops, Drug Resistance, Viral, Animals, Simplexvirus, Vero Cells

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
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