This article describes the development of a 6-item instrument that measures thirst distress. Items were developed following open-ended interviews with 10 subjects, a literature review, and development of a conceptual definition of thirst. A panel of experts established content validity. A convenience sample (N = 247) of adults receiving outpatient hemodialysis completed the scale. A panel of experts was used to assess content validity. Item analysis was used to select unrelated or redundant items for deletion. Cronbach's alpha was .78. Construct validity was supported by confirmatory and exploratory factor analysis. Positive relationships between thirst distress and, respectively, thirst intensity and interdialytic weight gain provided additional evidence of construct validity. Overall, these preliminary data indicate that the thirst distress scale has sufficient reliability and validity for use in clinical studies.