Ancylostomatidae (Necator) infections are endemic in the west part of Georgia. This is promoted by natural and socioeconomic conditions of the region. The baseline Ancylostomatidae infection rates in the population average 43%. The specific features of an epidemic process of Ancylostomatidae infections under different regional conditions were clinically and epidemiologically studied, which made it possible to start implementing a whole package of differential therapeutical and preventive measures purposefully. This caused a drastic and steady-state reduction in invasion in the population. By 1990, a Ancylostomatidae infection rate of 0.009% was achieved, which was much lower than that of virtual Ancylostomatidae infection eradication.