[Anti-atherosclerotic action of mildronate in experiment].
Copyright policy )[Anti-atherosclerotic action of mildronate in experiment].
Mildronate is a new antiischemic drug which inhibits biosynthesis of carnitine from butyrobetaine. We studied antiatherosclerotic and antiinflammatory effects of mildronate in guinea-pigs, rats and rabbits. We found a hypolipidemic action of this substance in rats with triton WR-1339 hyperlipidemia. A protective antiatherosclerotic effect of mildronate was observed in rabbits kept on the atherogenic diet for 3 months. Antiinflammatory efficiency of mildronate in rats was demonstrated after injection of bradykinin, carragenine or implantation of a small cotton-wool pad.
Inflammation, Arteriosclerosis, Anti-Inflammatory Agents, Non-Steroidal, Guinea Pigs, Cardiovascular Agents, Hyperlipidemias, Bradykinin, Lipids, Polyethylene Glycols, Rats, Lethal Dose 50, Liver, Animals, Rabbits, Methylhydrazines
Inflammation, Arteriosclerosis, Anti-Inflammatory Agents, Non-Steroidal, Guinea Pigs, Cardiovascular Agents, Hyperlipidemias, Bradykinin, Lipids, Polyethylene Glycols, Rats, Lethal Dose 50, Liver, Animals, Rabbits, Methylhydrazines
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