Mucocutaneous Candidiasis is discussed and his clinical aspects and immunologic mechanisms reviewed. On a series of 57 patients clinical presentation the antibodies patterns for IgE, IgG and IgM have been studied and the cellular response evaluated by flux cytometry decrease on Natural Killer cells NK, CD3-CD16+CD56+ was achieved in 55% of 51 patients and is the more relevant abnormality in cellular immunity. CD8 cytotoxic cells was also found in 8% of the patients. In some cases where Nk and CD8 cells were normal IgG antibodies were nul pointing to as relevant antibody dependent cellular cytotoxicity mechanisms in mucocutaneous Candidiasis.